These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antimalarial potency of the leaf extract of Aspilia africana (Pers.) C.D. Adams.
    Author: Christian AG, Mfon AG, Dick EA, David-Oku E, Linus AJ, Chukwuma EB.
    Journal: Asian Pac J Trop Med; 2012 Feb; 5(2):126-9. PubMed ID: 22221756.
    Abstract:
    OBJECTIVE: To investigate the antimalarial activity of ethanol extract of Aspilia africana (A. africana) leaf. METHODS: The ethanol extract of A. africana leaf (100-400 mg/kg) was screened for blood schizonticidal effect against chloroquine-sensitive Plasmodium berghei (P. berghei) in mice both in early and established models of antimalarial studies. RESULTS: The leaf extract exhibited significant (P<0.05) antiplasmodial activity in 4-day early infection and in established infection tests with a considerable mean survival time comparable to that of standard drug, chloroquine (10 mg/kg). CONCLUSIONS: The findings show that ethanol extract of A. africana leaf possesses potent antiplasmodial activity which justify the use in ethnomedicine and can be developed in malaria therapy.
    [Abstract] [Full Text] [Related] [New Search]