These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Anti IgE-induced asthma in guinea pigs; a new model for asthma. Physiological and pathological studies.
    Author: Ishii A, Ito K, Yamashita N, Miyamoto T, Shiga J, Watanabe N.
    Journal: Arerugi; 1990 Jun; 39(6):502-8. PubMed ID: 2222192.
    Abstract:
    We established an experimental animal model for IgE-mediated asthma by the use of intravenous injection of rabbit anti guinea pig IgE in normal guinea pigs. The degree of asthmatic airway obstruction was quantitatively estimated by Mead's apparatus which enabled us to use unanesthetized guinea pigs. With the injection of anti IgE, only an early asthmatic response was observed. Inhalation of anti IgE did not trigger asthma. Histo-pathological changes in the lung obtained immediately after the injection of anti IgE resembled those reported in human asthma. This system may be used for pathological and pharmacological studies of the IgE-dependent early asthmatic response.
    [Abstract] [Full Text] [Related] [New Search]