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  • Title: A practical strategy to create near-infrared luminescent probes: conversion from fluorescein-based sensors.
    Author: Terai T, Urano Y, Izumi S, Kojima H, Nagano T.
    Journal: Chem Commun (Camb); 2012 Mar 18; 48(23):2840-2. PubMed ID: 22222313.
    Abstract:
    Luminescent lanthanide complexes incorporating Yb(3+) and Nd(3+) are attracting much attention as imaging agents, but there have been few practical methods to make responsive sensors with these complexes. Here, we introduce a general strategy to synthesize near-infrared luminescent probes by conjugating a Yb(3+) chelate to established fluorescein-based probes. As the first demonstration, we present a complex, based on the green-emitting probe DAF-4, that responds to nitric oxide (NO) in aqueous solution with a significant increase in luminescence intensity at 980 nm.
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