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  • Title: IV lignocaine fails to attenuate the cardiovascular response to laryngoscopy and tracheal intubation.
    Author: Miller CD, Warren SJ.
    Journal: Br J Anaesth; 1990 Aug; 65(2):216-9. PubMed ID: 2223339.
    Abstract:
    I.v. lignocaine has been used with varying success to attenuate the cardiovascular responses to laryngoscopy and tracheal intubation. We determined the optimal time of administration in 45 ASA I and II Chinese patients premedicated with morphine and hyoscine, and anaesthetized with thiopentone and suxamethonium. Patients were allocated randomly to a control group or three treatment groups to receive lignocaine 1.5 mg kg-1 i.v. 1, 2, or 3 min before laryngoscopy. Analysis of variance for measured and derived cardiovascular variables failed to show any significant difference between any of the groups.
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