These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Role of stromal and Thy 1,2+ cells in the mechanisms of action of immobilized granulocyte colony-stimulating factor during cytostatic-induced myelosuppression.
    Author: Andreeva TV, Artamonov AV, Bekarev AA, Vereschagin EI, Madonov PG, Pershina OV, Skurikhin EG, Khmelevskaya ES, Dygai AM.
    Journal: Bull Exp Biol Med; 2011 Mar; 150(5):594-8. PubMed ID: 22235393.
    Abstract:
    The effects of immobilized granulocyte colony-stimulating factor (mediated by cells of the hemopoiesis-inducing microenvironment) on hemopoietic precursors of various classes were studied on the model of cytostatic-induced myelosuppression (administration of cyclophosphamide). The action of this preparation was compared with that of the standard preparation of granulocyte colony-stimulating factor. Thy 1,2(+)cells potentiated the effects of immobilized and standard granulocyte colony-stimulating factors on granulocyte-erythroid-macrophage-megakaryocyte precursors. Stromal cells were shown to potentiate the influence of these agents on granulocyte precursors. Induction of proliferation of precursor cells by the immobilized factor mediated by cells of the hemopoiesis-inducing microenvironment persisted for a longer period compared to that induced by the standard product.
    [Abstract] [Full Text] [Related] [New Search]