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  • Title: [Isolation of low molecular weight cytoplasmic regulators from the rat liver inducing the electrophoretic transport of K+ ions and phosphate across the inner mitochondrial membrane].
    Author: Gaĭnutdinov MKh, Zakharova TN, Ishmukhamedov RN, Konov VV, Safarov KS.
    Journal: Biokhimiia; 1990 Jul; 55(7):1257-65. PubMed ID: 2223900.
    Abstract:
    A water-soluble thermostable factor from rat liver cytoplasm whose activity decreases during starvation, causes the uncoupling of oxidative phosphorylation and stimulates pyruvate oxidation in rat liver mitochondria. The activity of this factor is insensitive to pronase treatment. Gel filtration and ion-exchange chromatography resulted in three low molecular weight water-soluble fractions which bear a negative charge at alkaline values of pH and induce electrophoretic transport of K+ and phosphate across the inner mitochondrial membrane. The effect of this factor on K+ transport is manifested at pH less than or equal to 7.0, that on phosphate transport-at pH 6.5-7.6.
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