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  • Title: [Index of microcirculatory changes in experimental dehydration in animals].
    Author: Tikhomirov AN, Stefanov SB, Suslov VB, Sokolov AV, Liubimtseva EA.
    Journal: Biull Eksp Biol Med; 1990 Jul; 110(7):26-8. PubMed ID: 2224090.
    Abstract:
    On the basis of morphokinetic synthesis principles the method of determination of summarizing criterion of microcirculatory system changes was developed. It consists of marked characteristics of changes of a number of the most important morphofunctional phenomena of each of this system compartments -- interstitial, lymphatic, blood and cellular -- with their successive summation to obtain the systemic microcirculation index. The experimental dehydration in rats being a model has shown that systemic microcirculatory index was 2 times as large in 3 days of dehydration, more than 3 times -- in 6 days, and 4, 5 times -- in 12 days. In the initial stage of the experiments maximal changes were found in interstitial compartment of the microcirculatory system. The intermediate period of dehydration differed by predominant changes of vascular compartment when the lymphatic phenomena were more evident than the hemomicrocirculatory ones. In the later stage of dehydration the cellular component changes of tissues and organs were predominant.
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