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  • Title: Treatment of antineutrophil cytoplasmic antibody-associated vasculitis: update.
    Author: Santana AN, Woronik V, Halpern AS, Barbas CS.
    Journal: J Bras Pneumol; 2011; 37(6):809-16. PubMed ID: 22241040.
    Abstract:
    In its various forms, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is characterized by a systemic inflammation of the small and medium-sized arteries (especially in the upper and lower respiratory tracts, as well as in the kidneys). The forms of AAV comprise Wegener's granulomatosis (now called granulomatosis with polyangiitis), microscopic polyangiitis, renal AAV, and Churg-Strauss syndrome. In this paper, we discuss the phases of AAV treatment, including the induction phase (with cyclophosphamide or rituximab) and the maintenance phase (with azathioprine, methotrexate, or rituximab). We also discuss how to handle patients who are refractory to cyclophosphamide.
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