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  • Title: [Role of stromal microenvironment in the regulation of bone marrow hemopoiesis after curantyl administration].
    Author: Ivasenko IN, Klestova OV, Arkad'eva GE, Almazov VA.
    Journal: Biull Eksp Biol Med; 1990 Jul; 110(7):98-100. PubMed ID: 2224116.
    Abstract:
    Role of the stromal microenvironment in regulation of bone marrow hemopoiesis at the administration of the thrombocyte disaggregant curantyl was studied by the method of heterotopic transplantation of the mice bone marrow. It is shown that the action of curantyl on hemopoiesis is realised through the stem stromal cells of the bone marrow. It is noted that the inhibitory action of the preparation on proliferation of osteogenic precursor-cells is followed by activation of bone resorption processes in regenerating ectopic hemopoietic organ. Under the action of curantyl at low bone marrow cellularity in the focus of heterotopic hemopoiesis and femur an increase of mitotic activity in hemopoietic elements is noted. It is revealed that a phenomenon of ineffective megakaryocytopoiesis with intramedullary destruction of megakaryocytes leads to the local excretion of the thrombocyte released growth factor (TRGF) which has a compensatory character.
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