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  • Title: [Vascular nephropathies: a fresh look at a systemic disease].
    Author: Boffa JJ.
    Journal: Presse Med; 2012 Mar; 41(3 Pt 1):298-303. PubMed ID: 22244726.
    Abstract:
    Hypertensive nephropathy represents the most prevalent cause of end-stage renal disease in France. Renal lesions are unspecific. Nephroangiosclerosis diagnosis is overestimated due to non standardized clinical criteria and available histological analysis. Other factors than hypertension contribute to vascular lesions.MYH9 and APOL1 polymorphisms are strongly associated with kidney diseases including hypertensive nephropathy. Elevated blood pressure levels are associated with CKD progression. Treatment includes angiotensin blockers which have a synergic effect on blood pressure reduction and lowering urinary protein excretion with sodium restriction and diuretics.
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