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  • Title: Synthesis and antimicrobial activity of 2,3-bis(bromomethyl)quinoxaline derivatives.
    Author: Ishikawa H, Sugiyama T, Kurita K, Yokoyama A.
    Journal: Bioorg Chem; 2012; 41-42():1-5. PubMed ID: 22245018.
    Abstract:
    We synthesized 12 derivatives of 2,3-bis(bromomethyl)quinoxaline with substituents at the 6- and/or 7-positions, and evaluated their activities against bacteria and fungi. Of the 12 compounds, nine (1a-h, 1j, and 1k) showed antibacterial activity. The derivative 1g, which bears a trifluoromethyl group at the 6-position, showed the highest activity against Gram-positive bacteria, while 1c, which has a fluoro-group at the 6-position, showed the widest antifungal activity spectrum. However, only the derivative with an ethyl ester substitution, 1k showed activity against Gram-negative bacteria.
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