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  • Title: Clinical implications of pharmacokinetics and pharmacodynamics of procedural sedation agents in children.
    Author: Sahyoun C, Krauss B.
    Journal: Curr Opin Pediatr; 2012 Apr; 24(2):225-32. PubMed ID: 22245909.
    Abstract:
    PURPOSE OF REVIEW: Procedural sedation has become the standard of care for managing pain and anxiety in children in the emergency department. RECENT FINDINGS: Numerous articles have been published on pediatric procedural sedation with, however, little in-depth discussion of the pharmacodynamics and pharmacokinetics of the sedation agents utilized. SUMMARY: We review the pharmacokinetics and pharmacodynamics of the pediatric procedural sedation pharmacopeia from a clinical perspective with emphasis on the practical implications for drug titration and dosing.
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