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  • Title: Biologically active bergenin derivatives from Bergenia stracheyi.
    Author: Siddiq F, Fatima I, Malik A, Afza N, Iqbal L, Lateef M, Hameed S, Khan SW.
    Journal: Chem Biodivers; 2012 Jan; 9(1):91-8. PubMed ID: 22253106.
    Abstract:
    New bergenin derivatives, bergecins A and B (1 and 2, resp.), have been isolated from the AcOEt-soluble fraction of Bergenia stracheyi, along with bergenin (3), and their structures were elucidated on the basis of (1) H- and (13) C-NMR spectra, and by COSY, HMQC, and HMBC experiments. Compound 2 showed potent inhibitory potential against the enzyme lipoxygenase, while 1 was moderately active. On the other hand, both compounds exhibited significant antioxidant activities in 1,1-diphenyl-2-picrylhydrazyl (DPPH) scavenging assay.
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