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Pubmed for Handhelds

PUBMED FOR HANDHELDS

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  • Title: Compact wireless neural recording system for small animals using silicon-based probe arrays.
    Author: Ruther P, Holzhammer T, Herwik S, Rich PD, Dalley JW, Paul O, Holtzman T.
    Journal: Annu Int Conf IEEE Eng Med Biol Soc; 2011; 2011():2284-7. PubMed ID: 22254797.
    Abstract:
    This paper reports on a compact, small-scale neural recording system combining state-of-art silicon-based probe arrays with a light-weight 32-channel wireless head stage. The system is equipped with two- and four-shaft, comb-shaped probe arrays connected to highly flexible ribbon cables enabling a reliable and controlled insertion of probe arrays through the intact dura mater into the medial prefrontal cortex and nucleus accumbens of rats. The in vivo experiments applied the 5-choice serial reaction time task (5-CSRTT) using freely behaving rats in order to understand the neural basis of sustained visual attention and impulsivity. The long-term stability of the system allowed local field potential (LFP) activity to be recorded without a significant decrement in signal quality for up to 28 weeks, and similarly, we were able to follow single unit activity for up to 4 weeks.
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