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  • Title: [Study on rat nasal absorption in situ of borneol based on single pass perfusion method].
    Author: Song X, Du S, Lu Y, Ma Y, Chen X, Wang Y, Zhang H.
    Journal: Zhongguo Zhong Yao Za Zhi; 2011 Sep; 36(18):2489-92. PubMed ID: 22256751.
    Abstract:
    OBJECTIVE: To investigate the absorption characteristic of borneol. METHOD: Using single pass perfusion model, the active ingredient of borneol were detected by GC. The drug concentration, perfusion rate and pH value on the absorption of borneol were studied. RESULT: Perfusion rate on the absorption rate constants (Ka) had significant effects. Drug concentration and pH value on the absorption rate constants had no significant impact. CONCLUSION: the absorption of borneol is good by nasal. The absorption rate constants of borneol have no effected by drug concentration. The absorption of borneol is via a simple diffusion.
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