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  • Title: [Anti-HIV activity and mechanism of Cynanchum otophyllum glucan sulfate in vitro].
    Author: Tao J, Yang J, Chen C, Zhao S, Ben K.
    Journal: Zhongguo Zhong Yao Za Zhi; 2011 Sep; 36(18):2548-51. PubMed ID: 22256764.
    Abstract:
    OBJECTIVE: To study anti-HIV activity and mechanism of Cynanchum otophyllum glucan sulfate in vitro. METHOD: Anti-HIV-1 activity was detected with syncytial formation assay and quantitative P24 enzyme-linked immunosorbent assay (ELISA); cytotoxicity was tested with MTT colorimetric assay. Antiviral mechanism was investigated by fusion inhibition, time of addition and pre-treatment experiments. RESULT: The 50% inhibition concentrations (IC50) of PS20 for HIV-1(IIIB), HIV-1(Ada-M), and HIV-1(Bal), were 0.26, 0.46, 0.90 micromol x L(-1), respectively. Studies on antiviral mechanism of PS20 showed that target molecule may be viral envelope protein. CONCLUSION: The results suggested that PS20 had high anti-HIV activity and was worth to be studied further.
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