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  • Title: Age-dependent changes of the protein synthetic machinery of liver cell cytoplasm as revealed by electron microscopic morphometry.
    Author: Giuli C, Pieri C, Zs-Nagy I.
    Journal: Aktuelle Gerontol; 1977 Oct; 7(10):547-8. PubMed ID: 22257.
    Abstract:
    Complete electron microscopic morphometric explorations of the liver were carry out in groups of 5 each young, adult and old female Wistar rats. In addition, livers were studied 1, 5, 10, 20 days after 2/3 hepatectomy in old rats. Characteristic age-dependent change: Decrease of the surface density of total endoplasmic reticulums between 1 and 12--27 months of age. After the partial hepatectomy the regenerated old liver "shows a certain" rejuvenation. The results suggest the validity of the theory of accumulation of somatic mutations during aging.
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