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  • Title: Autoimmune hemolytic anemia and immune thrombocytopenia as unusual presentations of childhood Hodgkin lymphoma: a case report and review of the literature.
    Author: Cecinati V, Brugnoletti F, D'Angiò M, De Nicolò MC, De Vellis A, Coluzzi S, Testi AM.
    Journal: J Pediatr Hematol Oncol; 2012 May; 34(4):280-2. PubMed ID: 22258348.
    Abstract:
    We discuss an unusual clinical presentation of childhood Hodgkin lymphoma; a 16-year-old girl was referred for Coombs-positive severe anemia, thrombocytopenia, and asymptomatic anterior mediastinal mass. Bone marrow examination showed no evidence of neoplastic disease. Biopsy of the mass was possible only after administration of both intravenous immunoglobulins and steroids resulting in a prompt rise of the platelet count and partial hemoglobin level stabilization. The identification of this clinical picture as a possible complication of an underlying Hodgkin lymphoma presents difficulties in diagnosis and management of the primary condition.
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