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  • Title: Synthesis, spectral studies and solvatochromic analysis of novel imidazole derivatives.
    Author: Jayabharathi J, Thanikachalam V, Srinivasan N, Venkatesh Perumal M.
    Journal: Spectrochim Acta A Mol Biomol Spectrosc; 2012 Apr; 89():194-200. PubMed ID: 22261107.
    Abstract:
    Bioactive imidazole derivatives were synthesized and characterized by spectral techniques. The photophysical properties of imidazole derivatives were studied in several solvents. The observed spectral shift is attributed to a loss of planarity in the excited state provided by the non-co-planarity of the aryl rings attached to C(2) and N(1) atoms of the imidazole ring. The observed solvatochromic shifts were analyzed in detail by Kamlet-Taft and Catalan parameters. The interaction between bioactive imidazole derivative and bovine serum albumin (BSA) was also investigated.
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