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  • Title: Clinical outcomes after lumbar fusion complicated by deep wound infection: a case-control study.
    Author: Petilon JM, Glassman SD, Dimar JR, Carreon LY.
    Journal: Spine (Phila Pa 1976); 2012 Jul 15; 37(16):1370-4. PubMed ID: 22261633.
    Abstract:
    STUDY DESIGN: A propensity score-matched case-control study. OBJECTIVE: To evaluate the 2-year clinical outcomes of patients who have undergone instrumented spinal fusions complicated by deep wound infections and compare them with a propensity score-matched control group who did not have infections. SUMMARY OF BACKGROUND DATA: Postoperative infection after instrumented spinal fusion is a major complication, often resulting in substantial short-term morbidity. However, there is little literature reviewing how these patients do in the longer term after their infection has been managed. METHODS: Thirty patients were identified who underwent instrumented lumbar spinal fusion with complete preoperative and 2-year postoperative outcome measures and had acute (#3 mo) postoperative deep wound infections necessitating irrigation and debridement. Outcome measures included the Oswestry Disability Index, 36-Item Short Form Health Survey Physical and Mental composite summaries, and numeric rating scales (0-10) for back and leg pain. A noninfected control group was identified using propensity score-matching techniques based on demographics, baseline clinical outcome measures, and surgical characteristics. Two-year postoperative outcome measures of both groups were compared. The proportion of patients achieving the minimum clinically important difference for the outcome measures was also assessed. Independent t tests were used to compare continuous variables, and Fisher exact test was used to compare categorical variables between the 2 groups. RESULTS: Consistent with the propensity score-matching technique, there were no significant demographic or surgical differences between the 2 study groups at baseline. Oswestry Disability Index, 36-Item Short Form Health Survey Physical Composite Summary, and back and leg pain scores were statistically significantly better at 2 years postoperative than at baseline in both groups. However, at 2 years postoperative, the infection group had a statistically significantly worse back pain score compared with the control group (6.45 vs. 4.70, P = 0.020). Also, a greater proportion of patients in the control group (18, 60%) achieved minimum clinically important difference for Oswestry Disability Index than those in the infection group (8, 27%, P = 0.018). CONCLUSION: This study demonstrates that patients with acute postoperative deep wound infections after instrumented lumbar spinal fusion have improved outcome measures after surgery but have greater back pain and a decreased probability of achieving minimum clinically important difference.
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