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  • Title: Copper-catalyzed C-alkylation of secondary alcohols and methyl ketones with alcohols employing the aerobic relay race methodology.
    Author: Liao S, Yu K, Li Q, Tian H, Zhang Z, Yu X, Xu Q.
    Journal: Org Biomol Chem; 2012 Apr 21; 10(15):2973-8. PubMed ID: 22261789.
    Abstract:
    By employing aerobic oxidation to aldehydes as a more effective alcohol activation strategy, ligand-free copper catalysts were found to be superior catalysts than other metals in aerobic dehydrative β-alkylation of secondary alcohols and α-alkylation of methyl ketones using alcohols as the green alkylating reagents. Based on our mechanistic studies and also supported by the literature, we deduce that the newly-proposed relay race process rather than the conventional borrowing hydrogen-type mechanisms should be the most possible and a more rational mechanism for the aerobic C-alkylation reactions.
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