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  • Title: Ganoderma atrum polysaccharide improves age-related oxidative stress and immune impairment in mice.
    Author: Li WJ, Nie SP, Peng XP, Liu XZ, Li C, Chen Y, Li JE, Song WR, Xie MY.
    Journal: J Agric Food Chem; 2012 Feb 15; 60(6):1413-8. PubMed ID: 22264032.
    Abstract:
    The aim of the present study was to investigate whether oxidative stress and immune dysfunction could be attenuated by Ganoderma atrum polysaccharide (PSG-1) in d-galactose (d-gal)-induced aging mice, and provide evidence for its effects. The results showed that PSG-1 significantly decreased lipid peroxidation in liver, brain, and spleen, but concomitantly increased the activities of superoxide dismutase, catalase, and glutathione peroxidase compared with the d-gal group. Elevation of glutathione contents and attenuation of glutathione disulfide contents were also found in PSG-1-treated animals. Furthermore, the results showed that PSG-1 treatment increased basal lymphocyte proliferation as well as T cell and B cell proliferation and enhanced interleukin-2 production. Taken together, the results suggested that PSG-1 had potential as a novel agent to promote health and improve aging-associated pathologies, at least in part, via modification of the redox system and improvement of immune function.
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