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  • Title: Effects of thyrotoxicosis on mitochondrial enzymes of rat soleus.
    Author: Courtright JB, Fitts RH.
    Journal: Horm Metab Res; 1979 Apr; 11(4):304-6. PubMed ID: 222661.
    Abstract:
    Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T3 + T4 treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerole-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T3 + T4 treated animals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers.
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