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  • Title: D1/D5 dopamine receptors modulate spatial memory formation.
    Author: da Silva WC, Köhler CC, Radiske A, Cammarota M.
    Journal: Neurobiol Learn Mem; 2012 Feb; 97(2):271-5. PubMed ID: 22266268.
    Abstract:
    We investigated the effect of the intra-CA1 administration of the D1/D5 receptor antagonist SCH23390 and the D1/D5 receptor agonist SKF38393 on spatial memory in the water maze. When given immediately, but not 3h after training, SCH23390 hindered long-term spatial memory formation without affecting non-spatial memory or the normal functionality of the hippocampus. On the contrary, post-training infusion of SKF38393 enhanced retention and facilitated the spontaneous recovery of the original spatial preference after reversal learning. Our findings demonstrate that hippocampal D1/D5 receptors play an essential role in spatial memory processing.
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