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  • Title: Temperature dependence of angiotensin II-mediated depolarisation of the rat isolated nodose ganglion.
    Author: Widdop RE, Krstew E, Jarrott B.
    Journal: Eur J Pharmacol; 1990 Aug 21; 185(1):107-11. PubMed ID: 2226630.
    Abstract:
    The ability of angiotensin II (A II) and 5-hydroxytryptamine (5-HT) to depolarise the rat isolated nodose ganglion preparation was examined. 5-HT depolarised the nodose ganglion, both at room temperature (20-24 degrees C) and at 35-37 degrees C. However, A II depolarised the nodose ganglion only under the latter condition, and these responses were blocked by the A II receptor antagonist saralasin. This study extends previous findings which have demonstrated A II binding sites on the nodose ganglion and axon, and identifies the rat nodose ganglion as a sensitive preparation in which to study the interactions between neuronal A II receptor activation and its blockade by A II receptor antagonists.
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