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  • Title: [The effect of a fluorocarbon emulsion--an enzyme inducer of the cytochrome P-450-dependent monooxygenase system of the liver--on the acute toxicity of CCl4 and on the efficacy of the prophylactic use of antidotes in organophosphate pesticide poisoning].
    Author: Mikhaĭlov GM, Varykhanov AA, Omarova LA, Verovskiĭ VE, Obraztsov VV.
    Journal: Farmakol Toksikol; 1990; 53(4):60-2. PubMed ID: 2226766.
    Abstract:
    The effect of intraperitoneal administration of perfluorocarbon emulsion, an inducer of cytochrome P-450-dependent monoxygenase system of the liver, on the resistance of rodents to the action of CCl4 and organophosphorus pesticides was studied. Perfluorocarbon emulsion potentiated CCl4 toxicity decreasing LD50 from 4.5 to 3.7 mg/kg mouse body weight without changing susceptibility of rats to organophosphorus pesticides. A preliminary administration of perfluorocarbon emulsion effectively increased the protective action of antidotes (atropine + dipyroxime) providing the resistance of the animals to 12-fold, 20-fold and 20-fold LD50 of dichlophos, methaphos and butiphos, respectively.
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