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  • Title: Effect of intraperitoneal administration of bacterial lipopolysaccharide on synthesis of pro-opiomelanocortin mRNA in rat tanycytes.
    Author: Sergeyev VG, Vegeyeva OA, Akmayev IG.
    Journal: Bull Exp Biol Med; 2011 Feb; 150(4):443-5. PubMed ID: 22268039.
    Abstract:
    Intensity of pro-opiomelanocortin mRNA synthesis in tanycytes of adrenalectomied and sham-operated rats was studied by in situ hybridization 4 h after intraperitoneal injection of bacterial LPS. The results were compared with pro-opiomelanocortin mRNA expression in rats subjected to immobilization stress. Immobilization and LPS injection to adrenalectomied and sham-operated animals sharply reduced pro-opiomelanocortin mRNA expression in tanycytes. Injection of LPS to sham-operated animals and immobilization stress caused a significant increase in blood corticosterone level. On the other hand, LPS injection did not change low blood level of corticosterone in adrenalectomied rats. The data indicate a synergic inhibitory effect of glucocorticoids and LPS on synthetic activity of tanycytes.
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