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  • Title: Generation of human endothelin by cathepsin E.
    Author: Lees WE, Kalinka S, Meech J, Capper SJ, Cook ND, Kay J.
    Journal: FEBS Lett; 1990 Oct 29; 273(1-2):99-102. PubMed ID: 2226872.
    Abstract:
    Highly-purified cathepsin D processed human big endothelin1-38 into endothelin-like fragments but did not appear to generate endothelin1-21 under the conditions employed. By contrast, human cathepsin E specifically cleaved human big endothelin into endothelin1-21 and the C-terminal fragment under identical conditions but did not degrade either product further.
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