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  • Title: Synthesis of 1,2,3-triazole glycoconjugates as inhibitors of α-glucosidases.
    Author: da Rocha DR, Santos WC, Lima ES, Ferreira VF.
    Journal: Carbohydr Res; 2012 Mar 01; 350():14-9. PubMed ID: 22269981.
    Abstract:
    Ten new 1,2,3-triazole glycoconjugates were synthesized from d-glucose and evaluated in in vitro assays for their ability to inhibit the enzyme α-glucosidase. Most of the compounds had low activity or were inactive when compared with acarbose. However, the derivative 1,2-O-isopropylidene-3-phenyl-5-(4-phenyl-1H-1,2,3-triazole-1-yl)-α-d-ribofuranose (19i) possessed activity comparable with the standard drug. The influence of the phenyl group on carbon 3 of the carbohydrate framework is discussed.
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