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  • Title: [Mechanism of action and therapeutic use of cyclosporin A. Experimental and clinical experiences in dermatology].
    Author: Laub R.
    Journal: Dermatol Monatsschr; 1990; 176(5-6):281-91. PubMed ID: 2227046.
    Abstract:
    The clinical application of cyclosporine A caused many success in transplantation surgery as well as in the treatment of (auto-) immune disorders. The biological highly active substance differs from conventional immunosuppressive drugs (i.e. steroids, azathioprine) by it's selective action on T-lymphocytes. However, current experimental findings indicate a direct influence on epidermal keratinocytes, too. First therapeutical experiences, concerning systemic and topical application in different skin diseases are summarized.
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