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  • Title: Panowamycins A and B, new antitrypanosomal isochromans produced by Streptomyces sp. K07-0010.
    Author: Hashida J, Niitsuma M, Iwatsuki M, Mori M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Matsumoto A, Ara I, Takahashi Y, Yamada H, Otoguro K, Shiomi K, Omura S.
    Journal: J Antibiot (Tokyo); 2012 Apr; 65(4):197-202. PubMed ID: 22274704.
    Abstract:
    Two new isochromans, panowamycins A and B, were purified by solvent extraction, silica gel and octadecylsilyl silica gel (ODS) column chromatography followed by preparative HPLC, from a culture broth of Streptomyces sp. K07-0010, together with the known compounds NFAT-133, conglobatin, piericidin C series and dinactin. Structures of panowamycins were elucidated as new analogs of NFAT-133 by spectroscopic studies including various NMR experiments. Panowamycins A and B showed moderate antitrypanosomal activity, with IC(50) values of 0.40 and 3.30 μg ml(-1), respectively.
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