These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association between genetic variations of vascular endothelial growth factor receptor 2 and glioma in the Chinese Han population.
    Author: Chen H, Wang W, Xingjie Z, Song X, Fan W, Keke Z, Chen G, Zhao Y, Mao Y, Lu D.
    Journal: J Mol Neurosci; 2012 Jul; 47(3):448-57. PubMed ID: 22274884.
    Abstract:
    Tumor angiogenesis, which is an important step in the development of cancer, is directly regulated by vascular endothelial growth factor receptor 2 (VEGFR-2). In this study, we examined the association of five potentially functional VEGFR-2 polymorphisms with glioma risk in a Chinese Han population. Three SNPs, rs2071559, rs7667298 and rs2305948, showed a statistically significant increased association with the risk of glioma (P = 0.006, 0.005, and 0.012, respectively). Both haplotype and diplotype analyses consistently revealed that subjects carrying two copies of the haplotype "CGT" had a 42% reduced glioma risk compared with their respective noncarriers. Our findings suggested that VEGFR-2 gene variants might contribute to glioma susceptibility.
    [Abstract] [Full Text] [Related] [New Search]