These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Effects of tea polyphenols on the activity of GSH-Px and NOS, and the content of MDA and NO in rats fed with high methionine diet].
    Author: Pei J, Guo S, Zhang C, Zhu Z, Yu L, Xie K, Zhao X.
    Journal: Wei Sheng Yan Jiu; 2011 Nov; 40(6):750-2. PubMed ID: 22279672.
    Abstract:
    OBJECTIVE: To study the effect of tea polyphenols (TP) on the content of malondialdehyde (MDA) and nitric oxide (NO) and the activity of GSH-Px and nitric oxide synthase (NOS) in rats fed with high methionine diet. METHODS: Wistar rats were randomly divided into 5 groups: model group, control group and 3 TP groups. Rats in model group and TP groups were fed with 3% methionine in diet, and rats in control group with routine diet. Rats in low-, midium- and high-dose TP groups were treated with 50, 100 and 200 mg/kg TP respectively by gavage every day for 8 weeks. Rats in control group and model group were given equal volume of distilled water. Activities of GSH-Px and NOS and contents of NO and MDA in serum were detected. Histopathological changes of aortic arc were observed by hematoxylin-eosin (HE) staining techniques. RESULTS: There were no statistically significant changes of GSH-Px activities among all groups. Compared with model group, MDA contents decreased by 27.1% in low-dose TP group (P < 0.01). Activities of NOS in TP groups increased respectively by 18.7%, 15.1% and 18.0% (P < 0.01), and NO contents in low- and high-dose TP groups increased by 113.4% and 73.4% (P < 0.01), respectively. A proliferation of vascular smooth muscle cells (VSMC) and increased thickness of aortic arch was observed in rats of model group, and these changes were suppressed in TP groups. CONCLUSION: Lipid peroxidation induced by high-methionine diet could be protected by TP. The function of endothelial cells could be maintained by increasing the NOS activity and NO contents, thus the injury of endothelial cells induced by high-methionine diet could be prevented and reduced by TP.
    [Abstract] [Full Text] [Related] [New Search]