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  • Title: Design, synthesis of some new (2-aminothiazol-4-yl)methylester derivatives as possible antimicrobial and antitubercular agents.
    Author: Karuvalam RP, Haridas KR, Nayak SK, Row TN, Rajeesh P, Rishikesan R, Kumari NS.
    Journal: Eur J Med Chem; 2012 Mar; 49():172-82. PubMed ID: 22280817.
    Abstract:
    A series of (2-aminothiazol-4-yl)methylester (5a-t) derivatives were synthesized in good yields and characterized by (1)H NMR, (13)C NMR, mass spectral and elemental analyses. The crystal structure of 5a was evidenced by X-ray diffraction study. The compounds were evaluated for their preliminary in vitro antibacterial, antifungal activity and were screened for antitubercular activity against Mycobacterium tuberculosis H37Rv strain. The synthesized compounds displayed interesting antimicrobial activity.
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