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  • Title: Induction of mutation to ouabain resistance and of malignant transformation by chemicals in cloned mouse M2 fibroblasts.
    Author: Marquardt H.
    Journal: Carcinogenesis; 1980 Mar; 1(3):215-8. PubMed ID: 22283002.
    Abstract:
    Malignant transformation and mutation to ouabain-resistance is induced in cloned M2 mouse fibroblasts in vitro by treatment with N-methyl-N'-nitro-N-nitrosoguanidine and two derivatives of polycyclic aromatic hydrocarbons, the 3,4-diol derived from 7-methylbenz [a]anthracene and the 7,8-diol-9,10-oxide derived from benzo[a]pyrene. Transformation is an event more frequent than mutation, the ratio of transformation to mutation frequencies varied between 24 and 1118. Another hydrocarbon derivative, the 9,10-diol-7,8-oxide derived from benzo[a]pyrene, did induce ouabain-resistance without causing transformation. Induced ouabain-resistant clones did not behave like transformants, and transformants did not exhibit ouabain resistance. The significance of these findings is discussed.
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