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  • Title: Extensively drug-resistant tuberculosis: experience at the Tuberculosis Research Centre, Chennai, India.
    Author: Thomas A, Joseph P, Nair D, Rao DV, Rekha VV, Selvakumar N, Jaggarajamma K, Balambal R.
    Journal: Int J Tuberc Lung Dis; 2011 Oct; 15(10):1323-5. PubMed ID: 22283888.
    Abstract:
    Ten extensively drug-resistant tuberculosis (XDR-TB) patients were identified among 104 human immunodeficiency virus negative multidrug-resistant tuberculosis (MDR-TB) patients treated at the Tuberculosis Research Centre, Chennai, India, in two different cohorts between 1999-2003 and 2006-2007. They were managed with individualised treatment regimens. At the time of diagnosis of MDR-TB, one patient had XDR-TB and three had initial ofloxacin resistance. One patient who had had a lobectomy in addition to chemotherapy became bacteriologically negative, three died, three defaulted and the remaining three, who are bacteriologically positive, are still continuing treatment. Although based on a small number of patients, our results have not been encouraging.
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