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  • Title: Voriconazole pharmacokinetics and photosensitivity in children with cystic fibrosis.
    Author: Markantonis SL, Katelari A, Pappa E, Doudounakis S.
    Journal: J Cyst Fibros; 2012 May; 11(3):246-52. PubMed ID: 22284963.
    Abstract:
    BACKGROUND: A high incidence of adverse skin reactions following long-term oral administration of voriconazole in children with cystic fibrosis and allergic bronchopulmonary aspergillosis (ABPA). The aim was to study the pharmacokinetics of voriconazole in these patients and to determine a possible association between drug levels and adverse effects. METHODS: Multiple venous blood samples were collected for HPLC determination of voriconazole concentrations and routine blood tests. Adverse events were recorded. RESULTS: No significant correlation was found between incidence of photosensitivity and voriconazole serum levels in 6 of 8 children with ABPA. 80% of patients had trough voriconazole concentrations<1000 ng/mL and were highly variable. CONCLUSIONS: Long-term voriconazole therapy and greater sun exposure in Greece appear to play a major role in the occurrence of photosensitivity. Steady-state plasma drug concentrations were found to be highly variable and below the recommended therapeutic range in most patients, without any apparent negative influence on outcome.
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