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  • Title: Enhancement of crystallization with nucleotide ligands identified by dye-ligand affinity chromatography.
    Author: Kim H, Webster C, Roberts JK, Kositsawat J, Hung LW, Terwilliger TC, Kim CY.
    Journal: J Struct Funct Genomics; 2012 Jun; 13(2):71-9. PubMed ID: 22286688.
    Abstract:
    Ligands interacting with Mycobacterium tuberculosis recombinant proteins were identified through use of the ability of Cibacron Blue F3GA dye to interact with nucleoside/nucleotide binding proteins, and the effects of these ligands on crystallization were examined. Co-crystallization with ligands enhanced crystallization and enabled X-ray diffraction data to be collected to a resolution of atleast 2.7 Å for 5 of 10 proteins tested. Additionally, clues about individual proteins’ functions were obtained from their interactions with each of a panel of ligands.
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