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  • Title: Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients.
    Author: Kuroi K, Sato Y, Takayama T, Baba N, Yamaguchi Y, Toge T.
    Journal: Hiroshima J Med Sci; 1990 Jun; 39(2):23-7. PubMed ID: 2228724.
    Abstract:
    Lymphocyte subpopulations in peripheral blood and the spleen from gastric cancer patients were identified by either single or two color analysis with fluorescence activated cell sorter-IV (FACS-IV) using monoclonal antibodies. The absolute and percentages of CD3+ (mature T) cells and CD4+ (helper/inducer T) cells in peripheral blood from the advanced cancer patients were significantly lower than those from normal healthy controls. In peripheral blood, a significant decrease of CD4+ cells was due to the decrease of CD4+ CD45RA+ (suppressor inducer T) cells, while CD8+ CD11b+ (suppressor T) cells tended to increase with progress of the disease. CD4+ CD45RA+ cells located more predominantly in peripheral blood and spleen than in the splenic vein, while CD8+ CD11b+ cells were more predominant in the splenic vein.
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