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  • Title: Ontogeny of normal human B-cell and T-cell precursors and its relation to leukemogenesis.
    Author: LeBien TW, Villablanca JG.
    Journal: Hematol Oncol Clin North Am; 1990 Aug; 4(4):835-47. PubMed ID: 2228898.
    Abstract:
    The concept that a pluripotent stem cell exists and has the capacity eventually to give rise to mature B and T cells is uncontestable. However, the precise developmental relationship between pluripotent stem cells and the earliest stages of B-cell and T-cell development are still obscure. Patterns of gene expression are being identified that characterize normal B-cell and T-cell precursors, and the regulatory variables that influence self-renewal and differentiation of these cells. These are important studies because childhood lymphoblastic leukemia almost always manifests a cellular phenotype consonant with an immature lymphoid cell. A comprehensive understanding of the etiology of acute lymphoblastic leukemia will likely be hastened by a more thorough understanding of normal lymphopoiesis. This knowledge will complement the large data base that currently characterizes lymphoblastic leukemia in children.
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