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  • Title: Sputum adenosine deaminase and alkaline phosphatase activity in pulmonary tuberculosis.
    Author: Jadhav AA, Jain A.
    Journal: Arch Physiol Biochem; 2012 Feb; 118(1):6-9. PubMed ID: 22289040.
    Abstract:
    OBJECTIVE: The aim was to determine adenosine deaminase (ADA) and alkaline phosphatase (ALP) activity in sputum for the diagnosis of pulmonary tuberculosis. METHODS: This study comprised of 64 subjects (33 pulmonary tuberculosis and 31 lung cancer). The ADA and ALP activity was measured in sputum and serum. RESULTS: The mean ADA activity in sputum, serum and mean sputum/serum ADA ratio was 205.20 IU/L, 42.32 IU/L and 4.90 in pulmonary tuberculosis and 127.74 IU/L, 29.90 IU/L and 4.27 in lung cancer subjects respectively. The mean ALP activity in sputum, serum and mean sputum/serum ALP ratio was 461.34 IU/L, 159.24 IU/L and 2.90 in pulmonary tuberculosis and 226.64 IU/L, 119.87 IU/L and 1.99 in lung cancer subjects respectively. CONCLUSION: The mean ADA and ALP activity was significantly increased in pulmonary tuberculosis as compared to lung cancer subjects and hence may be a useful tool for the diagnosis of pulmonary tuberculosis.
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