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  • Title: The pyrrolo[2,1-a]isoquinoline alkaloids.
    Author: Pässler U, Knölker HJ.
    Journal: Alkaloids Chem Biol; 2011; 70():79-151. PubMed ID: 22308756.
    Abstract:
    The present chapter describes isolation, biogenetic proposals, and syntheses of the natural products 1-4 and 10-11 with a pyrrolo[2,1-a]-isoquinoline framework. Moreover, the syntheses of some structural analogs are discussed. The pyrrolo[2,1-a]isoquinolines are of interest due to their promising biological activities. For crispine A (1), many total syntheses have been reported and for trolline (3), only three. Only one total synthesis has been reported for each of the following natural products: peyoglutam (10), mescalotam (11), and the antitumor active crispine B (2). Some of the pyrrolo[2,1-a]isoquinoline alkaloids have not been synthesized yet. The following three tables summarize the synthetic efforts toward crispine A (1) (Table 1: racemic syntheses; Table 2: enantioselective syntheses) and trolline (3) (Table 3).
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