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  • Title: Growth and development in a child with resistance to thyroid hormone and ectopic thyroid gland.
    Author: Heather N, Hall K, Neas K, Potter H, Wiltshire E.
    Journal: Pediatrics; 2012 Mar; 129(3):e817-20. PubMed ID: 22311990.
    Abstract:
    Resistance to thyroid hormone is an uncommon problem, which has rarely been associated with thyroid dysgenesis. We report a case with both thyroid gland ectopy and resistance to thyroid hormone and, thus, a reduced capacity to produce and respond to thyroid hormone. The patient presented at 2 years of age with developmental delay, dysmorphic features, and elevation in both thyroxine and thyrotropin. We document her response to therapy with thyroxine, with particular regard to her growth and development. Persistent elevation of thyrotropin is commonly recognized during treatment of congenital hypothyroidism. Resistance to thyroid hormone may be an important additional diagnosis to consider in cases where thyrotropin remains persistently elevated.
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