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  • Title: Cholesterol goal attainment in hypertensive patients: the impact of metabolic syndrome components.
    Author: Rodrigues CJ, Ribeiro HF, Ribeiro AB, Zanella MT, Batista MC.
    Journal: Metab Syndr Relat Disord; 2012 Jun; 10(3):195-201. PubMed ID: 22313142.
    Abstract:
    BACKGROUND: Hypertension and dyslipidemia are potentially modifiable cardiovascular risk factors. METHODS: We studied hypertensive outpatients regarding goal attainment in controlling dyslipidemia, according to individual cardiovascular risk profile, following the National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) guidelines. Factors of goal attainment for low-density lipoprotein cholesterol (LDL-C) were determined. RESULTS: Of the 1,202 patients, this study included 886 (73.8% female, 59.9±11.1 years) with available data to determine cardiovascular risk. Overall, 544 (61.4%) had LDL-C within the goal. Individuals with inappropriate LDL-C were older, had higher systolic blood pressure (SBP), and were more likely to have metabolic syndrome, diabetes, and cardiovascular disease (CVD) and were less likely to show a controlled blood pressure. There was a progressive worsening of LDL-C control as the number of components of metabolic syndrome increased. There was also a progressive increase in the percentage of patients with inappropriate LDL-C with the increase in cardiovascular risk. In a logistic regression model including LDL-C inadequacy as a dependent variable, only age, diabetes, and CVD were predictors of inappropriate LDL-C. Moreover, even with correction for demographic and clinical variables, the inappropriate LDL-C was an independent predictor of CVD. CONCLUSIONS: The control of dyslipidemia in hypertensive patients is far from ideal and results are even worse in individuals with CVD.
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