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  • Title: Uterine leiomyosarcoma producing granulocyte colony stimulating factor.
    Author: Nakayama K, Nakayama N, Rahman MT, Rahman M, Katagiri H, Katagiri A, Ishikawa M, Ishibashi T, Iida K, Harada Y, Miyazaki K.
    Journal: Int J Gynecol Pathol; 2012 Mar; 31(2):172-177. PubMed ID: 22317876.
    Abstract:
    Uterine leiomyosarcoma associated with the paraneoplastic production of granulocyte-colony stimulating factor (GCSF) is extremely rare. No case has been reported to date in the English literature. We describe a case of a 56-year-old female with recurrent uterin leiomyosarcoma, associated with leukocytosis (19100/mm) and an elevated serum GCSF (33.0 pg/ml). Tumore histology was consistent with a well differentiated leiomyosarcoma with marked neutrophilic infiltration of the lung and spleen metastases. tumor cells were distinctly positive for GCSF on immunohistochemistry. These findings confirmed the diagnosis of a GCSF-producting uterine leiomyosarcoma with a paraneoplastic leukocytosis.
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