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  • Title: Application of click chemistry to the production of DNA microarrays.
    Author: Uszczyńska B, Ratajczak T, Frydrych E, Maciejewski H, Figlerowicz M, Markiewicz WT, Chmielewski MK.
    Journal: Lab Chip; 2012 Mar 21; 12(6):1151-6. PubMed ID: 22318451.
    Abstract:
    The copper-catalyzed alkyne-azide cycloaddition (CuAAC) reaction was applied as the novel method of DNA immobilization on a modified solid support. The CuAAC click reaction enables the covalent binding of DNA modified with pentynyl groups at its 5'-end to azide-loaded slides. Click microarrays were produced using this approach and successfully employed in biological/model experiments.
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