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  • Title: Evidence for a dual versus single origin of the MMNs evoked by cued versus cueless deviants.
    Author: Hoonhorst I, Deltenre P, Markessis E, Collet G, Pablos Martin X, Colin C.
    Journal: Clin Neurophysiol; 2012 Aug; 123(8):1561-7. PubMed ID: 22321294.
    Abstract:
    OBJECTIVE: This study was designed to separately test the effect of the cued/cueless nature of deviant stimuli and that of temporal distance between sound and deviance onsets on the mismatch negativity (MMN) as well as to look for discrepancies between behavioural discrimination performances and MMN amplitude when deviants are cueless. METHODS: Ten healthy adults passively listened to stimuli that were contrasted by the presence or absence of a frequency sweep starting early or late within the sound. Discrimination performances were collected after the electrophysiological sessions. RESULTS: MMNs were much larger for cued than for cueless deviants. The temporal distance between sound and deviance onsets affected MMNs evoked by both cued and cueless deviants, even to the point of abolishing the MMN when cueless deviance occurred late in the stimulus. Behavioural data were at ceiling levels for all conditions, contrasting with the absence of MMN evoked by cueless deviants with late onset. CONCLUSIONS: Two mechanisms contribute to the MMN evoked by cued deviants: the memory comparison process and the adaptation/fresh-afferent one. Within the temporal window of integration, the delay at which each component disappears is different. SIGNIFICANCE: Comparing waveforms evoked by cued versus cueless deviants provides a fairly simple way of isolating the MMN memory-based component.
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