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  • Title: Crystallization, spectral, crystallographical, and thermoanalytical studies of succinobucol polymorphism.
    Author: Jurček O, Lahtinen M, Wimmer Z, Drašar P, Kolehmainen E.
    Journal: J Pharm Sci; 2012 May; 101(5):1794-802. PubMed ID: 22323097.
    Abstract:
    Four different polymorphs, A, C, D, and E, of succinobucol were isolated and characterized by means of solid-state nuclear magnetic resonance spectroscopy, single crystal and powder X-ray diffraction, differential scanning calorimetry, thermogravimetry, and attenuated total reflection-infrared spectroscopy. From a number of experiments, the same polymorphs (C, D, and E) and an equilibrium phase mixture B consisting of polymorphs C and D were repeatedly gained using different solvents or their mixtures. Although polymorph A was obtained directly from recrystallization only on few occasions, polymorphs C, D, and E proved to be metastable kinetic polymorphs, which slowly transform to a thermodynamically more stable form A during long-term storage. The single-crystal structures of polymorph C and D were determined by X-ray single-crystal diffraction.
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