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  • Title: [Two cases of pulmonary alveolar proteinosis with increased CEA].
    Author: Takanashi S, Nakamura K, Yuasa K, Kudo M, Takase H, Kushibiki D, Kimura T, Yasugahira H, Sawada M, Onodera K.
    Journal: Nihon Kyobu Shikkan Gakkai Zasshi; 1990 Jul; 28(7):1006-11. PubMed ID: 2232373.
    Abstract:
    Two cases of pulmonary alveolar proteinosis (PAP) with increased CEA were reported. Case 1 was a 62-year-old male with suspected pulmonary fibrosis, who was transferred to our hospital. Laboratory findings on admission revealed 31.3 ng/ml of CEA. Because he had severe dyspnea, lung biopsy was not carried out. His condition gradually deteriorated and he died of respiratory failure. Autopsy revealed he had PAP and no malignancy. Case 2 was a 48 year-old male referred to our hospital because of dyspnea. Serum CEA was 52.8 ng/ml. Microscopic examination of a transbronchial lung biopsy showed PAP. The level of CEA in bronchoalveolar lavage fluid was 151 ng/ml. Unilateral whole lung lavage was performed twice. With the improvement of chest X-ray findings, serum levels of CEA fell to normal level. The molecular weight of CEA in bronchoalveolar lavage fluid was 180,000. Immunochemical staining of CEA in lung revealed nonspecific findings.
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