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  • Title: [Changes in lipid fractions of blood during the treatment of hypertension with prazosin and trasicor].
    Author: Rugenius IuIu, Damiĭonaĭtene RA, Kuchinskene ZZ, Vidugiris AI, Steponenene RV.
    Journal: Kardiologiia; 1990 Jul; 30(7):14-5. PubMed ID: 2232454.
    Abstract:
    The paper deals with the study into the benefits of prazosin and trasicor used in arterial hypertension. Their effects on the blood lipid composition were evaluated. With prazosin, the steady antihypertensive effect was reached in 81.0%, whereas with trasicor, it was attained in 46%. When prazosin was given, total cholesterol and triglycerides were statistically significantly decreased by 6.8 and 14.8%, respectively, while high density lipoproteins was increased by 9.1%. When trasicor was administered, no changes were observed in the spectrum of serum lipids. Thus, prazosin is effective in correcting two major risk factors for coronary heart disease, namely arterial hypertension and hyperlipoproteinemia, thereby reducing a risk for coronary heart disease.
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